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KMID : 0602820100160020109
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Korean Journal of Bronchoesophagology
2010 Volume.16 No. 2 p.109 ~ p.114
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Sentinel Lymph Node Identification Using 99mTc-Neomannosyl Human Serum Albumin in Esophageal Cancer; Comparison with 99mTc-Phytate
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Kim Hyun-Koo
Kang Du-Young
Kim Sung-Eun
Park Jong-Jae
Jeong Jae-Min
Mok Young-Jae
Choi Young-Ho
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Abstract
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Background: The aim of this study was to compare a novel mannose receptor-binding agent(Technetium-99m human serum albumin, 99mTc-MSA) with 99mTc-phytate for sentinel node mapping in patients with esophageal cancer.
Material and Method: Twenty patients with clinical stage T1N0m0 or T2N0M0 esophageal cancer that were candidates for esophagectomy were enrolled. Endoscopic injection of 99mTc-MSA or99mTc -phytate was administered at the peri-tumor region before surgery in 10 patients. The radioactive lymph nodes were identified with a handheld gamma probe after lymph node dissection.
Results: The patient’s age and the sex ratio of both groups were similar. The clinical stage, tumor location, and operative technique did not differ. The total number of dissected lymph nodes did not differ ( in MSA group, in phytate group, p=0.430). The sentinel node was identified in all cases in both groups. The number of sentinel nodes per patient was in the MSA group, which was significantly greater than the in the phytate group (p=0.036). Five out of 20 patients whose sentinel nodes could be identified had metastases; however, neither group had any false-negative results for sentinel node identification.
Conclusion: Sentinel nodes were detected more frequently with MSA than with phytate.
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KEYWORD
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Esophageal cancer, Sentinel lymph node, Lymph node dissection, Surgery
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